The ultimate creative challenge is to make something with artistic merit that is also wildly popular. Being experimental is necessary to allow your work to grow and breathe, but the cutting edge can be a place to just visit and refuel. Don't lock yourself inside the ghetto of the avant-garde out of arrogance or fear of success. Bring the new and unfamiliar out to the greet the masses.
It is possible to embrace a wide audience without dumbing your work down, and if we all take this approach perhaps there could be far more intelligence in the mainstream.
There is no prize for being misunderstood.